Effects of gamma interferon and indomethacin in preventing Brucella abortus infections in mice

Abstract

Increased resistance to infection with Brucella abortus 2308 resulted when recombinant murine gamma interferon (rMuIFN-γ) was given to mice both before and during infection but not when given only before infection. Mice given rMuIFN-γ had enhanced peritoneal and splenic macrophage bactericidal activity against B. abortus. Treatment of mice with rMuIFN-γ plus indomethacin did not further enhance resistance to infection or macrophage bactericidal activity compared with that after treatment of mice with rMuIFN- γ alone.