Transformation of hashimoto thyroiditis to Graves’ disease

Abstract

Hashimoto's thyroiditis and Graves' disease are thyroid-specific autoimmune disorders with distinct pathological mechanism. Clinical presentation and histopathological features also vary greatly in these disorders. Sequential conversation from Hashimoto's thyroiditis (HT) to Graves' disease (GD) has been rarely reported throughout the world. Herein, we report a woman with history of HT, who then developed GD requiring total thyroidectomy. By reporting this case, we hope to raise awareness about this phenomenon among clinicians and illustrate the potential mechanisms behind such change. Improving recognition and identification of this potential conversation between HT and GD would allow clinicians to expeditiously implement appropriate treatment, increasing the quality of care.