Cytotoxic prenylated flavonoids from the stem bark of maackia amurensis

Abstract

Five new prenylated flavonoids, maackiaflavanone A (1), maackiaflavanone B (2), maackiapentone (3), maackiapterocarpan A (4), maackiapterocarpan B (5) along with eleven known flavonoids were isolated from the stem bark of Maackia amurensis. The structures of the new compounds were elucidated by spectroscopic methods. The cytotoxicities of compounds 1-4, 6, 8-12 and 14-16 against four human cancer cell lines, A375S2, HeLa, MCF-7 and HepG2, were tested by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. Among the compounds tested, compound 2 showed the strongest cytotoxic activity with IC50 value of 7.8 μm against A375S2 and euchrenone b1 showed the most potent cytotoxicity with IC50 value of 4.5 μm against HeLa. © 2009 Pharmaceutical Society of Japan.