C1q/TNF-related protein 4 (CTRP4) is a unique secreted protein with two tandem C1q domains that functions in the hypothalamus to modulate food intake and body weight

Abstract

Background: CTRP4 is a conserved member of the C1q family of secreted proteins with poorly defined function. Results: CTRP4 acts in the hypothalamus to modulate food intake and body weight by regulating the expression of orexigenic neuropeptide expression. Conclusion: CTRP4 plays a role in food intake regulation. Significance: This study establishes the first known in vivo function of CTRP4. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc..