Acceptability of a Culturally Tailored eHealth Video Intervention “Put Yourself First” to Promote Preexposure Prophylaxis Awareness and Knowledge Among Young Black Women: Mixed Methods Pilot Study

Abstract

Background: Black women experience dual disparities with disproportionately high rates of HIV infection and low uptake of preexposure prophylaxis (PrEP). To address this issue, a culturally relevant eHealth video intervention was developed to increase awareness and uptake of PrEP. Objective: This study aims to evaluate the usability, acceptability, and impact of a culturally tailored eHealth video intervention (“Put Yourself First”) on PrEP-related knowledge and motivation among young Black women. Methods: This study used a sequential, mixed methods design. Thirteen young, primarily heterosexual, Black women, aged 18-25 years, were recruited from community-based organizations and social networks in New York City to participate in 2 evaluation focus groups. Participants completed pre- and postvideo assessments, followed by facilitated focus group discussions to elicit qualitative feedback on the video’s usability, acceptability, and impact on PrEP knowledge. Results: After watching the eHealth video, knowledge scores increased significantly postviewing (P=.04). Most participants indicated willingness to consider PrEP (10/13, 77%), and all reported intentions to recommend it to others (13/13, 100%). Overall, 92% (12/13) of the participants rated the video as very good or excellent. Participants found the video to be very interesting (11/13, 85%) and useful (12/13, 92%). The qualitative findings suggest that representation, authenticity, and the normalization of PrEP use emerged as critical drivers of acceptability. It also highlighted the video’s relatability, cultural relevance, and ability to dispel misconceptions, while also identifying areas for refinement for future studies. Conclusions: Findings support the acceptability and usability of culturally tailored sex-positive eHealth interventions for improving PrEP awareness and motivation among young Black women. Culturally resonant multimedia centering the voices of young Black women to affirming pleasure, agency, and addressing structural barriers to engagement offers a promising strategy for HIV prevention.