Diversified construction of chromeno[3,4-c]pyridin-5-one and benzo[c]chromen-6-one derivatives by domino reaction of 4-Alkynyl-2-oxo-2H- chromene-3-carbaldehydes

Abstract

Silver-catalyzed three-component, tandem reactions of 4-alkynyl-2-oxo-2H- chromene-3-carbaldehydes, amines and various nucleophiles result in the formation of highly functionalized chromeno[3,4-c]pyridin-5-ones in high yields. Gold-catalyzed [4+2] cycloadditions of 4-alkynyl-2-oxo-2H-chromene-3- carbaldehydes with alkynes or alkenes have also been achieved to afford benzo[c]chromen-6-ones efficiently. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.