Abstract
Cyslabdan, a new potentiator of imipenem activity against methicillin-resistant Staphylococcus aureus, was isolated from the culture broth of Streptomyces sp. K04-0144 by Diaion HP-20 and ODS column chromatographies and preparative HPLC. The structure of cyslabdan was elucidated by spectroscopic analyses including NMR. The compound has a labdane-type diterpene skeleton connecting with an N-acetylcysteine via thioether linkage. © Japan Antibiotics Research Association.
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Fukumoto, A., Kim, Y. P., Matsumoto, A., Takahashi, Y., Shiomi, K., Tomoda, H., & Omura, S. (2008). Cyslabdan, a new potentiator of imipenem activity against methicillin-resistant Staphylococcus aureus, produced by Streptomyces sp. K04-0144: I. Taxonomy, fermentation, isolation and structural elucidation. Journal of Antibiotics, 61(1), 1–6. https://doi.org/10.1038/ja.2008.101
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