Enantioseparation using amylose esters as chiral stationary phases for high-performance liquid chromatography

Abstract

Novel amylose ester derivatives were synthesized and their chiral recognition abilities as chiral stationary phases for highperformance liquid chromatography were evaluated. Compared with amylose benzoate derivatives, cinnamate derivatives showed a higher chiral recognition ability and some racemates could be efficiently resolved. The recognition abilities of these derivatives varied significantly depending on the types and positions of substituents introduced into the phenyl group. Among the prepared derivatives, the nonsubstituted cinnamate derivative showed a relatively high chiral recognition, and interestingly, its ability was influenced by the preparation conditions of packing materials using silica gel as a support. © The Society of Polymer Science, Japan (SPSJ) All rights reserved.