Nanoparticle Formation and Delivery of Poorly Water-soluble Drugs by Hydrophobized Polymers

Abstract

When a hydrophobic group is introduced into a water-soluble polymer, self-assembly with the hydrophobic group as nucleus occurs in water. In the 1990s, many researchers focused on this phenomenon and various self-aggregates were prepared. Among them, a block copolymer consisting of a hydrophilic chain and a hydrophobic chain is associated in water, producing polymer micelles with the hydrophilic chain oriented in the outer shell and the hydrophobic chain as core. Meanwhile, many studies were conducted to create polymer self-associates by introducing hydrophobic groups into water-soluble polymers. In this review, the author describes hydrophobized polymers with polysaccharides and synthetic polymers that are frequently used as pharmaceutical raw materials. In addition are outlined the usefulness of hydrophobized polymers as carriers with the function of encapsulating and solubilizing poorly water-soluble drugs, along with the results of our research.