Production of actinomycin-D by the mutant of a new isolate of Streptomyces sindenensis

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Abstract

An actinomycin-D producing strain was isolated from soil and characterized as Streptomyces sindenensis. The culture was subjected to UV irradiation and a mutant with 400% higher actinomycin-D production was isolated (400 mg/l -1 as compared to 80 mg/l-1 produced by the parent). Production medium was optimized and antibiotic yield with the mutant was enhanced to 850 mg/l-1 which is 963% higher as compared with the parent.

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Praveen, V., Tripathi, C. K. M., Bihari, V., & Srivastava, S. C. (2008). Production of actinomycin-D by the mutant of a new isolate of Streptomyces sindenensis. Brazilian Journal of Microbiology, 39(4), 689–692. https://doi.org/10.1590/S1517-83822008000400017

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