The plasma membrane calcium pump in pancreatic cancer cells exhibiting the warburg effect relies on glycolytic ATP

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Abstract

Background: Pancreatic cancer cells exhibit up-regulated glycolysis (the "Warburg effect"). Results: Reversing the Warburg phenotype protects pancreatic cancer cells from glycolytic inhibitor-induced ATP depletion, plasma membrane calcium pump (PMCA) inhibition, and [Ca2+]i overload. Conclusion: Glycolytic ATP is critical for PMCA function in pancreatic cancer. Significance: The glycolytic dependence of the PMCA may represent a novel therapeutic target in pancreatic cancer.

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James, A. D., Patel, W., Butt, Z., Adiamah, M., Dakhel, R., Latif, A., … Bruce, J. I. E. (2015). The plasma membrane calcium pump in pancreatic cancer cells exhibiting the warburg effect relies on glycolytic ATP. Journal of Biological Chemistry, 290(41), 24760–24771. https://doi.org/10.1074/jbc.M115.668707

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