Preparation of nano spherical bioglass by alkali-catalyzed mixed template

Abstract

Nano bioactive glasses (NBGs) were fabricated by alkali-catalyzed sol-gel combined with self-assembly template technique using ammonia and dodecylamine as dual-alkali catalysts. Its effect of the addition of cetyltrimethyl ammonium bromide (CTAB) in NBGs on its morphology and bioactivity were characterized. It is found that the incorporation of CTAB can adjust the diameter of particles from 23 nm to 48 nm and the NBGs can induce hydroxyapatite deposition on the surface. With the increase of CTAB, the size of particle decreased while its mineralization activity in vitro was enhanced. Thus, this study provides an available method to synthesize spherical nano bioglass with controllable particle size.