Metabolism of Budralazine, a New Antihypertensive Agent. Identification of the Metabolites of Budralazine in Rats

Abstract

The metabolism of budralazine in rats was investigated. Ten urinary metabolites were detected and identified after oral administration. Major metabolites were 3-methyl-s-triazolo[3,4-α]phthalazine and 1-(s-triazolo[3,4-α]phthalazine-3-carboxy)-β-D-gluco-pyranosiduronic acid. Comparison of the metabolic pattern obtained in spontaneously hypertensive rat and normotensive Wistar-strain rat was also discussed. But no significant difference was observed for the time course of biotransformation rate between them. © 1976, The Pharmaceutical Society of Japan. All rights reserved.