Effect of Sodium Copper Chlorophyllin on Lipid Peroxidation. IX. On the Antioxidative Components in Commercial Preparations of Sodium Copper Chlorophyllin

Abstract

Two antioxidative components in commercial preparations of sodium copper chlorophyllin were isolated as their methyl esters. Through the identification of the methyl esters by comparison with authentic samples and the saponification of the methyl esters, disodium copper isochlorin-e4 and trisodium copper chlorin-e6 were demonstrated to be included in sodium copper chlorophyllin as constituents. The antioxidative activities of both sodium copper chlorins on Fe2+and ascorbic acid-induced lipid peroxidation in rat liver homogenates were about 8-fold greater than that of sodium copper chlorophyllin. The two components were concluded to play a principal role in the antioxidative action of sodium copper chlorophyllin. © 1986, The Pharmaceutical Society of Japan. All rights reserved.