Abstract
Isoprostanes (IsoPs) and neuroprostanes (NeuroPs) are formed in vivo by a free radical non-enzymatic mechanism involving peroxidation of arachidonic acid (AA, C20:4 n-6) and docosahexaenoic acid (DHA, C22:6 n-3) respectively. This review summarises our research in the total synthesis of these lipid metabolites, as well as their biological activities and their utility as biomarkers of oxidative stress in humans. © 2013 Elsevier Ltd. All rights reserved.
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Galano, J. M., Mas, E., Barden, A., Mori, T. A., Signorini, C., De Felice, C., … Durand, T. (2013). Isoprostanes and neuroprostanes: Total synthesis, biological activity and biomarkers of oxidative stress in humans. Prostaglandins and Other Lipid Mediators. https://doi.org/10.1016/j.prostaglandins.2013.04.003
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