Interaction of receptor for advanced glycation end products with advanced oxidation protein products induces podocyte injury

Abstract

Chronic kidney disease (CKD) is characterized by progressive decline in renal function. Podocyte dropouts contribute to the pathogenesis of diabetic and nondiabetic CKD. Zhou and colleagues demonstrate that the association between advanced oxidation protein products (AOPPs) and receptor for advanced glycation end products (RAGE) elicited podocyte injuries, using cultured podocytes and mice injected with AOPPs. This study suggests that the blockade of RAGE is preventive and therapeutic against podocyte apoptosis caused by oxidative stress-related AOPPs in CKD. © 2012 International Society of Nephrology.