Preservation of postural control of transient lower oesophageal sphincter relaxations in patients with reflux oesophagitis

Abstract

Introduction - In normal subjects, transient lower oesophageal sphincter relaxations (TLOSRs) and gas reflux during belching are suppressed in the supine position. Supine reflux, however, is a feature of reflux disease. Aims - To investigate whether postural suppression of TLOSRs and gas reflux is impaired in patients with reflux disease. Patients - Ten patients with erosive oesophagitis. Methods - Oesophageal manometry was performed during gastric distension with 750 ml carbon dioxide. Measurements were made for 10 minutes before and after distension in both sitting and supine positions. Results - In the sitting position gastric distension substantially increased the rate of gas reflux (median (interquartile range)), as evidenced by increases in oesophageal common cavities from 1 (0-1)/10 min to 7 (5-10)/10 min and TLOSRs from 1 (1-1.5)110 min to 6 (2.5-8)/10 min. However, this effect was suppressed in the supine position in all but one patient (TLOSRs 0 (0)/10 min to 1 (0-4.5)/10 min, common cavities 0 (0)/10 min to 0.5 (0-2)/10 min). Conclusions - Postural suppression of TLOSRs and gas reflux is generally preserved in reflux disease.