In-Vitro Assessment of Synthesized Hydroxyapatite Specimen in Simulated Body Fluid (SBF)

Abstract

Recently, the patient that requires bone replacement has increase, especially the patients who suffering from bone cancer, trauma and ageing. This attracts attention of researchers related to biomaterial fields to synthesis materials from biomaterials waste for bone tissue replacements. Hydroxyapatite was identified as a suitable source for bone substitution due its excellent bioactivity and biocompatibility. The strategies for tissue engineering include developing those cells to form the required tissue/organ in-vitro before inserting them into the body. This study is aimed to investigate In-Vitro properties of hydroxyapatite (HAp) specimens synthesize from the clamshells via precipitation method. HAp moulded specimen were immersed in the simulated body fluid (SBF). It displayed that the development of apatite layers materialized in the surface of HAp after being immersed for 25 days in the 1.5SBF.