Synthesis of {3-(2-dimethylamino-ethy1)-2-[3-(2-dimethylaminoethyl)-1H- indol-5-ylmethyl]-1H-indol-5-yl}-N-methyl-methanesulfonamide, the main Sumatriptan impurity

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Abstract

An improved multistep synthesis of {3-(2-dimethylamino-ethy1)-2-[3-(2- dimethylaminoethyl)-1H-indol-5-ylmethyl]-1H-indol-5-yl}-N-methyl- methanesulfonamide, the main Sumatriptan impurity, is described, as a model for other related triptan derivatives. ©ARKAT USA, Inc.

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Sanz, A., Carril, A. M. G., Matía, M. P., Novella, J. L., & Alvarez-Builla, J. (2008). Synthesis of {3-(2-dimethylamino-ethy1)-2-[3-(2-dimethylaminoethyl)-1H- indol-5-ylmethyl]-1H-indol-5-yl}-N-methyl-methanesulfonamide, the main Sumatriptan impurity. Arkivoc, 2008(2), 53–58. https://doi.org/10.3998/ark.5550190.0009.207

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