Abstract
In STRIDE, slow metabolizer CYP2B6 and NAT2 genotypes were each associated with increased plasma efavirenz concentrations during antituberculosis therapy. Concentrations were greater on therapy than off therapy in 58% with CYP2B6 and 93% with NAT2 slow metabolizer genotypes. Individuals with slow metabolizer genotypes in both genes had markedly elevated concentrations.
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Luetkemeyer, A. F., Rosenkranz, S. L., Lu, D., Grinsztejn, B., Sanchez, J., Ssemmanda, M., … Haas, D. W. (2015). Combined effect of CYP2B6 and NAT2 genotype on plasma efavirenz exposure during rifampin-based antituberculosis therapy in the STRIDE study. Clinical Infectious Diseases, 60(12), 1860–1863. https://doi.org/10.1093/cid/civ155
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