Abeliaside, a new phenolic glucoside from Abelia triflora

Abstract

A new phenolic glucoside, abeliaside, along with four known compounds, 5,6,7,4′-tetrahydroxy flavones, caffeic acid, 4-O-caffeoylquinic acid and caffeic acid glucoside, was isolated from the leaves of Abelia triflora R. Br. (Caprifoliaceae). The structure of the new compound was elucidated by different spectroscopic techniques. Compounds 1-5 were assayed for their anticancer activities against two cancerous human cell lines, MCF-7 and PC-3 cells, and normal Vero cell line using the crystal violet staining method. From the results it could be seen that caffeic acid possessed the highest anticancer effect against MCF-7 (IC50: 17 g/mL) and PC-3 (IC50: 20.1 g/mL) compared to vinblastine sulphate as reference drug (IC50: 4.6, 2.8 g/mL). The other compounds showed weak anticancer activity on both cell lines.