Methyl 3-(5-(prop-1-yn-1-yl)thiophen-2-yl)propanoate: A Rare Acetylene Derivative from Artemisia absinthium Root Essential Oil

Abstract

Methyl 3-(5-(prop-1-yn-1-yl)thiophen-2-yl)propanoate (1), biosynthetically and structurally related to dehydromatricaria ester, was isolated from the root essential oil of Artemisia absinthium L. (0.7% of the total oil). This is the second record of this compound and the very first one regarding it as an essential-oil constituent. In this paper, we give details regarding its isolation, structural elucidation and gas chromatographic properties (RI on DB-5 MS column: 1694). The NMR-based identification of the compound was corroborated by simulation of its 1H- and 13C-NMR spectra using a GIAO method (DFT level of theory). A tentative biosynthetic pathway, possibly leading to this compound, is also proposed.