Inhibition of 5-lipoxygenase selectively triggers disruption of c-Myc signaling in prostate cancer cells

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Abstract

Background: Frequent overactivation of c-Myc aggravates a spectrum of cancers. However, cancer-specific inhibition of c-Myc activity poses significant difficulty.

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Sarveswaran, S., Chakraborty, D., Chitale, D., Sears, R., & Ghosh, J. (2015). Inhibition of 5-lipoxygenase selectively triggers disruption of c-Myc signaling in prostate cancer cells. Journal of Biological Chemistry, 290(8), 4994–5006. https://doi.org/10.1074/jbc.M114.599035

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