Application of Biaryl Phosphacycles in Palladium-Catalysed Suzuki-Miyaura Cross-Coupling Reactions of Aryl Chlorides

Abstract

The use of Pd-catalysts based on biaryl phosphacycles allowed facile Suzuki-Miyaura couplings of a wide range of deactivated, sterically hindered, and heteroaryl chloride substrates with aryl boronic acids. Notably, the strongly electron-deficient and sufficiently hindered biaryl phosphacycle ligand 7 consistently demonstrated effective performance.