Hemoglobin-Related Biomaterials and their Applications

Abstract

Hemoglobin (Hb) is a physiological oxygen-transport metalloprotein present in the red blood cells. With the in-depth study, many functions of Hb are developed, and kinds of Hb-related biomaterials are applied for biomedical therapeutics in the past decades. Herein, the recent advances of Hb-related biomaterials and their applications, including the clinical progress of Hb-based oxygen carriers (HBOCs) as blood substitutes, and the applications in the field of tumor therapy, wound healing, and anti-inflammation therapy through utilizing its function of multiple gas delivery (O2, CO, NO), peroxidase-like catalysis, and targeting macrophage, are summarized. With the rapid development of science and technology, more versatile Hb-related biomaterials are designed in the future for other applications.