Association of retinol binding protein- 4 (RBP4) with glycemia, dyslipidemia, hypertension, and obesity in type 2 diabetic Iraqi patients

Abstract

Retinol binding protein 4 (RBP4), an adipokine that participate in a lipid metabolism or insulin resistance through a complex regulatory network. Recently, RBP4 was reported to be associated with many cardiovascular diseases (CVDs) risk factors in type 2 diabetes mellitus (T2DM) patients. This study aims to study the correlation of serum RBP4 with some markers of glycemic control, dyslipidemia, hypertension, and obesity in T2DM Iraqi patients. One hundred twenty (120) T2DM patients were enrolled in this cross-sectional study. Serum RBP4 levels are higher in T2DM patients with dyslipidemia, hypertension, or obesity. The diference was statistically non significant between hypertensive and normotensive T2DM patients. Serum RBP4 is positively correlated with body mass index, fasting blood glucose, glycosylated hemoglobin (HbA1c), systolic blood pressure (P<0.001), and low density lipoprotein cholesterol (P<0.05), and negatively correlated with high density lipoprotein cholesterol (P<0.001). Serum RBP4 is correlated with many risk factors of CVD including, poor glycemic indices, dyslipidemia, hypertension, and obesity, in T2DM Iraqi patients.