New Triruthenium Clusters as Photoinduced DNA-binding and Cleaving Agents¶

Abstract

1-Hydroxybenzotriazole and 1-hydroxypyridine-2-thione were incorporatedas ligands with the cluster Ru 3 (CO) 10 (NCMe) 2 to give [(μ-H)Ru 3 (CO) 10 (μ 2 -2,3-η 2 -NNN(O)C 6 H 4)] and [(μ-H)Ru 3 (CO) 9 (μ 2 -η 1 :η 2 -C 5 H 4 N(O)S)], respectively. Irradiationof these two new triruthenium metal clusters individually with 350nm UV light in a phosphate buffer (pH 6.0) containing form I DNAresulted in single-strand cleavage. Cluster [(μ-H)Ru 3 (CO) 10 (μ 2 -2,3-η 2 -NNN (O)C 6 H 4)]was also found to bind to calf thymus DNA upon UV irradiation.