Abstract
We report that primary human vaginal dendritic cells (DCs) display a myeloid phenotype and express CD4, CCR5, and CXCR4. Vaginal CD13 + CD11c + DCs rapidly and efficiently bound transmitted/founder (T/F) CCR5-tropic (R5) viruses, transported them through explanted vaginal mucosa, and transmitted them in trans to vaginal and blood lymphocytes. Vaginal myeloid DCs may play a key role in capturing and disseminating T/F R5 HIV-1 in vivo and are candidate “gatekeeper” cells in HIV-1 transmission.
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CITATION STYLE
Shen, R., Kappes, J. C., Smythies, L. E., Richter, H. E., Novak, L., & Smith, P. D. (2014). Vaginal Myeloid Dendritic Cells Transmit Founder HIV-1. Journal of Virology, 88(13), 7683–7688. https://doi.org/10.1128/jvi.00766-14
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