FORMULATION, CHARACTERIZATION AND IN-VITRO EVALUATION OF FLOATING MICROSPHERE OF IBUPROFEN USING CARBOPOL 940 POLYMER

Abstract

In this study, ibuprofen hollow microspheres are prepared and assessed using a novel emulsion-solvent diffusion process in an effort to increase the drug's enteric bioavailability by extending the duration of the drug's stomach residence. Carbopol 940, drug, ethanol, and the DCM solution were added to an agitated PVA aqueous solution that was thermally regulated to 40 degrees Celsius to create microspheres. The resultant microspheres were separated through filtration and subjected to various evaluations like micrometrics characteristics, morphology, in vitro floating behaviour, percentage of drug entrapment, and in vitro drug release. According to in vitro release experiments, formulation F3 was found to be 86.75 % in 10 hrs. It is possible to draw the conclusion from the study that microspheres are the perfect tool for increasing the length of time a drug is present in the stomach and improving its enteric bioavailability.