STUDY ON THE ANTIOXIDANT, ANTIBACTERIAL, AND CYTOTOXIC ACTIVITIES IN VITRO OF ROOT EXTRACTS FROM CODONOPSIS JAVANICA IN KON TUM PROVINCE, VIETNAM

Abstract

Dangshen Codonopsis javanica performed high medicinal properties in herbal remedies; however, there is currently not much specific analysis for phytochemicals and bioactivities of this plant. In this study, the ethanol extract of C. javanica roots obtained from Kon Tum Province, Vietnam contained several substances as saponin, phenolic acid, terpenoid and alkaloid. The antibacterial effect of the extract showed against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Bacillus cereus with the IC50 value of 150, 100, 150 and 90 μg/ml, respectively. The antioxidant capacity of the extract also displayed IC50 value of 46.8 ± 6.8 μg/ml. Moreover, the anticancer ability of the extract exhibited on two human cancer HepG2 cells (IC50 = 83.6 ± 2.7 μg/ml), and MCF-7 cells (IC50 = 95.3 ± 2.3 μg/ml). Hence, this study for the first time provide the basic data for further research of bioactivities of natural compounds Dangshen C. javanica.