The incidence and mortality rate of cervix cancer in Iran from 1990 to 2016: A systematic review and meta-analysis Running title: Cervix cancer in Iran

Abstract

Objective: Cervix Cancer (CC) is one of the major health problems among Iranian women and elsewhere around the world. Considering the importance of this cancer, the present study was conducted to determine the age-standardized incidence rate (ASIR) and age-standardized mortality rate (ASMR) of CC in Iran. Methods: A search was conducted using international databases (Medline/PubMed, ProQuest, Scopus, Embase and ISI/ web of knowledge), and national databases (Scientific Information Database, MagIran, IranMedex, and IranDoc). This systematic review was carried out according to the preferred reporting items for systematic reviews and meta-analyses (PRISMA) check list in 2018. Thereafter, Persian and English language papers referring to the ASIR and ASMR of CC in Iran were included. Data were independently extracted by two reviewers. The Joanna Briggs checklist was carried out to evaluate the quality of studies. Result: A total of 522 papers were obtained in the initial search of the databases, and 25 articles were included to the review by further refinement and screening. Based on the random-effect model, the ASIR and ASMR of CC in Iran was 2.14 per 100000, 95% CI (1.89 to 2.38) and 0.93 per 100000, 95% CI (0.81 to 1.05), respectively. Conclusion: The incidence and mortality of CC in Iran was lower than other parts of the world. It should be noted that because of the high heterogeneity of the results of this study, we must judge with caution regarding the results.