Occurrence of Carbapenem Resistant Klebsiella pneumoniae in Clinical Samples from Some Selected Hospitals in Zaria, Kaduna State

Abstract

Aims: The aim of the study was to determine the occurrence of carbapenem resistant Klebsiella pneumoniae in clinical samples from some selected hospitals in Zaria, Kaduna state. 2 resistance to Imipenem is likely due to other mechanism such as decreased outer membrane permeability, over expression of β-lactamases, production of cephalosporinase and porin loss but not due to carbapenemase production. Carbapenem resistant Klebsiella pneumoniae in Zaria as seen in this study occurs at the rate of 0% and that of KPC producing Klebsiella pneumoniae occurs also at 0%. Conclusion: Even though the level of carbapenem resistance was low and none of the isolates was a KPC producer, most of the isolates were multidrug resistant isolates and this is alarming.