Effects of thiamine on lipid metabolism in magnesium deficient rats

Abstract

Six different synthetic diets were given to wistar rats for four weeks Group 1, thiamine and magnesium deficient; group 2, thiamine deficient, magnesium sufficient; group 3, thiamine adequate, magnesium deficient; group 4, thiamine adequate, magnesium sufficient; group 5, thiamine ex-cess, magnesium deficient; group 6, thiamine excess, magnesium sufficient. Triglyceride, cholesterol, and total lipid levels in the livers of group 3 and 5 rats increased significantly. These values decreased in groups 1 and 2. Incorporation of 14C-acetate to liver lipid or cholesterol fractions increased in magnesium deficient groups (groups 3 and 5) rather than in the magnesium containing groups (groups 4 and 6). This increase was most prominent in the thiamine and magnesium deficient (group 1) and thiamine deficient magnesium sufficient groups (group 2). © 1973, Center for Academic Publications Japan. All rights reserved.