A review: continuous renal replacement therapy for sepsis-associated acute kidney injury

Abstract

Sepsis is a series of systemic inflammatory reactions induced by infection and trauma, which can cause significant organ damage. Continuous renal replacement therapy (CRRT), a new alternative to renal therapy, is a long-term and continuous external blood purification therapy that lasts for 24 h. This procedure can remove metabolic toxins and inflammatory mediators in the body, as well as correct water electrolyte disorders and acid-base and immune imbalances. This article reviews the clinical application of CRRT in the treatment of sepsis-associated acute kidney injury and analyzes its underlying mechanisms in the treatment of sepsis, thereby providing a theoretical basis for the clinical treatment of sepsis. Highlights Hemodynamic and non-hemodynamic mechanisms underlying sepsis-associated AKI. Inflammatory and oxidative stress factors mediate AKI. CRRT has therapeutic advantages and prospects in AKI.