A review on tablet binders as a pharmaceutical excipient

Abstract

The tablet formulation contains binders that increase the inter-particulate bond power inside the tablet. Research and progress of novel accessories remains a priority for potential use as a binder in formulations tablet. Tablet binder or binding agent are the substances that are added either dry or in liquid form during wet granulation to form granules or to promote cohesive compacts for directly compressed tablets. E.g., starch, pregelatinized starch, PEG, sorbitol, and HPMC, etc. Tablet Binder and disintegrants have the opposite used in an oral solid formulation. Binder delay tablet disintegration while disintegrant increase tablet disintegration. They play a vital role in making sure pellets or granules and tablets remain in shape until they reach their target by holding all ingredients (API and Excipients) together in any solid dosage form. Selecting the correct binder is critical to maintaining the integrity of the tablet. Natural binders such as various starches, Gums, mucus and dried fruits, among other things, have the ability to bind. Features such as Natural polymers, fillers, and disintegrants are also safe more economical than synthetic polymers.