Controlled trial of combinations of hydroxocobalamin cystine and riboflavine cystine, in Nigerian ataxic neuropathy

Abstract

Chronic cyanide intoxication of dietary origin and riboflavine deficiency are believed to be major etiological factors in Nigerian tropical ataxic neuropathy. The results are presented of a double blind controlled therapeutic trial of combinations of large doses of hydroxocobalamin and cystine as cyanide binding agents, together with riboflavine or placebos, in Nigerian patients suffering from the tropical ataxic neuropathy. No clinical benefit was demonstrable with any of the treatments.