P293 Influence of initial albumin levels on infliximab and adalimumab trough levels in inflammatory bowel disease patients

Abstract

S249 Results: 76 patients were consecutively included, 30 (39%) men. Fifty-five (72%) Crohn's disease (CD) and 21 (28%) ulcerative colitis (UC),46 (60%) had maintenance treatment with IFX and 30 (40%) with ADA. Mean weight was 68 kg. Initial mean albumin was similar (4.0 vs. 4.1 g/dl) in male and female groups. ADA trough levels were affected more than IFX trough levels by initial albumin values. When albumin is below 4 g/dl, ADA concentrations were lower (7.0 vs. 8.8 μg/ml (p = 0.06), with 24.7% increase when albumin was >4 g/dl. In IFX the influence of albumin was very small (3.3 vs. 3.6 μg/ml with an increase of 8.9% when albumin >4 g/dl) Influence of initial albumin in trough levels Body weight affected drug ADA and IFX differently. In IFX it had no influence, but below 80 kg, ADA concentrations remained constant (8.9 μg/ml). However in>80 Kg patients, concentrations dropped to 6.7 μg/ml. In relation to gender, mean drug concentrations were 3.6/3.5 μg/ml (male/female) in IFX group and 7.5/9.0 μg/ml in ADA group (p = 0.08). No significant changes in drug concentrations were observed between the CD and UC groups (9.05 vs. 8.31 μg/ml, 3.42 vs. 3.64 μg/ml, ADA and IFX respectively). Background: Crohn's disease (CD) is a chronic inflammatory disease that can affect any section of the gastrointestinal tract. Malnutrition is a common sequel in CD patients and many pathogenic mechanisms could be involved such as poor dietary intake, altered energy expenditure, nutrient malabsorption and/ or losses. Aim: This cross-sectional study aimed to evaluate the resting energy expenditure (REE) in CD patients. Methods: All consecutive adult CD women were prospectively enrolled, while a group of healthy women, matched for age and