Prenylated benzene metabolites from melicope pteleifolia

Abstract

Chemical investigation on the stem and root of Melicope pteleifolia afforded three new prenylated benzene metabolites as racemic mixtures, named pteleifolins A-C (1-3, resp.). Their gross structures were elucidated on the basis of spectroscopic analysis, especially 2D-NMR experiments. An enantiomer resolution of (±)-1 using chiral HPLC was performed, and the absolute configuration of the enantiomers were determined to be (+)-(S)-1 and (-)-(R)-1 by means of circular-dichroism analysis. Copyright © 2013 Verlag Helvetica Chimica Acta AG, Zürich, Switzerland.