Interneuronal transfer and distal action of tetanus toxin and botulinum neurotoxins a and D in central neurons

Abstract

Botulinum neurotoxins (BoNT/A, BoNT/D), and tetanus toxin (TeNT) enter neurons via two separate entry pathways: a canonical synaptic vesicle recycling pathway that leads to local effects, and a distinct secondary uptake pathway that directs these toxins to a common, non-acidified, retrograde carrier.