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Evaluation of antibiofilm agents for treatment of cystic fibrosis-related chronic rhinosinusitis

International Forum of Allergy and Rhinology (2025) 15(1) 73-76
DOI: 10.1002/alr.23441
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Abstract

Key points: Treatment of cystic fibrosis-related chronic rhinosinusitis should target sinonasal biofilms. NaHCO3 salts with/without xylitol have limited antibiofilm properties, whereas rhDNAse has not. Phage effectivity varies and depends on the phage and the combination with antibiotics.

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Uyttebroek, S., Dupont, L., Wagemans, J., Lavigne, R., Merabishvili, M., Coenye, T., & Van Gerven, L. (2025). Evaluation of antibiofilm agents for treatment of cystic fibrosis-related chronic rhinosinusitis. International Forum of Allergy and Rhinology, 15(1), 73–76. https://doi.org/10.1002/alr.23441

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