Chitosan encapsulation enhances the bioavailability and tissue retention of curcumin and improves its efficacy in preventing b[a]p-induced lung carcinogenesis

Abstract

The rate of lung cancer incidence is alarmingly studies showed sustained release of curcumin over a mounting, despite the decline of smoking and tobacco period of approximately 180 hours and excellent intra-consumption. Recent reports indicate a very high cor-cellular uptake and cytotoxicity in lung cancer cells. relation between the growing fast food culture and lung Bioavailability studies using healthy Swiss albino mice cancer incidence. Benzo[a]pyrene (B[a]P) is a potent demonstrated drastic enhancement in lung localization carcinogen abundantly present in grilled and deep-fried of chitosan nanocurcumin compared with free curcu-food and in tobacco smoke. Our previous studies have min. Toxicologic evaluation using chronic toxicity mod-proved the efficacy of curcumin in curbing B[a]P-el in Swiss albino mice confirmed the pharmacologic induced lung carcinogenesis. However, the poor phar-safety of the formulation. Moreover, the formulation, macokinetic profile of the compound considerably even at a dose equivalent to one fourth that of free hampers its potential as an effective chemopreventive. curcumin, exhibits better efficacy in reducing tumor This study was intended to evaluate whether encapsu-incidence and multiplicity than free curcumin, thereby lation of curcumin in chitosan nanoparticles can hampering development of B[a]P-induced lung adeno-improve the cellular uptake and prolong the tissue carcinomas in Swiss albino mice. Hence, our study retention of curcumin yielding better chemoprevention. underscores the supremacy of the formulation over The curcumin-loaded chitosan nanoparticles (chitosan free curcumin and establishes it as a potential chemo-nanocurcumin) exhibited a size of 170–200 nm in preventive and oral supplement against environmental transmission electron microscopy. In vitro drug release carcinogenesis.