Effects of immunization procedures in experimental toxoplasmosis

Abstract

1. Toxoplasma vaccines were prepared from whole and sonically-disrupted organisms, and administered to mice with or without Freund's adjuvants. None of these vaccines proved effective against a subsequent challenge with the lethal RH strain of Toxoplasma gondii. 2. Passive immunization of mice with rabbit and pig antisera likewise failed to protect mice against a RH challenge. 3. The passive transfer of peritoneal exudate cells from immune to non-immune mice was ineffective, although diffusion chamber studies indicated that immune macrophages were able to inhibit the growth and multiplication of RH trophozoites. © 1965, The Keio Journal of Medicine. All rights reserved.