Production and physicochemical characterization of cu-doped silicate bioceramic scaffolds

Abstract

Development of ion-releasing implantable biomaterials is a valuable approach for advanced medical therapies. In the effort of tackling this challenge, we explored the feasibility of porous bioceramic scaffolds releasing copper ions, which are potentially able to elicit angiogenetic and antibacterial effects. First, small amounts of CuO were incorporated in the base silicate glass duringmelting and the obtained powders were further processed to fabricate glass-ceramic scaffolds by sponge replica method followed by sinter crystallization. As the release of copper ions fromthese foams in simulated body fluid (SBF)was very limited, a second processing strategy was developed. Silicate glass-ceramic scaffolds were coated with a layer of Cu-doped mesoporous glass, which exhibited favorable textural properties (ultrahigh specific surface area > 200m2/g, mesopore size about 5 nm) formodulating the release of copper. All the produced scaffolds, containing biocompatible crystals of wollastonite (CaSiO3), revealed high stability in a biological environment. Furthermore, the materials had adequate compressive strength (> 10MPa) for allowing safe manipulation during surgery. Overall, the results achieved in the present work suggest that these Cu-doped glass-derived scaffolds show promise for biomedical application and motivate further investigation of their suitability from a biological viewpoint.