Recent advances of direct trifluoromethylthiolation

Abstract

Compounds containing trifluoromethylthio group (SCF3) play an important role in pharmaceuticals, agrochemicals and materials due to its strong electron-withdrawing effect and extremely high lipophilicity. Very recently, trifluoromethylthiolation has received a great attention. In this review, the new progress of direct trifluoromethylthiolation is described. Furthermore, the synthetic challenge for trifluoromethylthiolation is also discussed.