Bio Synthesis of Beta Vulgaris Mediated ZnO Nanoparticles and Their Anti-Bacterial, Anti-Fungal, Anti-Diabetic and Anti-Cancer Activities

Abstract

Plant extract mediated metal or metal oxide nanoparticles is a promising alternate to the chemical and physical methods. Application of nanoparticles in various fields get increased widely due to their properties. Current study involves the eco-friendly method of synthesis and pharmacological applications of zinc oxide nanoparticles (ZnO-NPs) using the aqueous beetroot (Beta vulgaris) extract. Aqueous Beta vulgaris extract has multiple bio-active phytochemicals especially antioxidants like anthocyanins and betacyanins, also reported a rich source of minerals. Synthesized ZnONPs were characterized with the aid of UV-Vis spectroscopy, FTIR, SEM, XRDand EDX. Antibacterial results suggests that, Beta vulgaris mediated ZnONPspossessthe maximum zone of inhibition against Escherichia coli then Staphylococcus aureus. On anti-fungal activity synthesized ZnONPS revealed greater inhibitory effect against Candida albicans fungi than the Aspergillusflavus. Synthesized ZnONPs exhibits the noticeable pharmacological activities against the anti-diabetic and anti-cancer activities (MCF-7 cell line, IC50=35.4µg/ml). This study has suggested an effective replacement for the hazardous chemical methods and lead to a cost-effective, environmentally -friendly method which can also be used as an antimicrobial, anti-diabetic and anti-cancer agents.