Intracellular Acid-Base Regulation. II. The Interaction between CO2 Tension and Extracellular Bicarbonate in the Determination of Muscle Cell pH *

Abstract

In the preceding paper (2) we showed that the acidity of resting skeletal muscle in vitro can be readily changed by variations in external [HCOl-] as well as by variations in CO. tension. In those studies one factor was varied while the other was kept normal, and so we obtained no informa- tion about possible interactions between CO2 ten- sion and extracellular bicarbonate in the control of cell pH.