Novel Cytocidal Compounds, Oxopropalines From Streptomyces Sp. G324 Producing Lavendamycin I. Taxonomy of the Producing Organism, Fermentation, Isolation and Biological Activities

Abstract

In the course of our investigation aimed at the discovery of novel antitumor antibiotics from microorganisms, Streptomyces sp. G324 was found to produce the antitumor antibiotic, lavendamycin, and also, to yield the novel β-carboline compounds, oxopropalines. Weisolated five compoundsas oxopropalines A, B, D, E and G. Oxopropalines B, D and G showed cytocidal activities against humanor murine tumor cell lines in vitro. © 1993, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.