Cytotoxic alkaloids and a flavan from the bulbs of Crinum asiaticum var. japonicum

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Abstract

A new pyrrolophenanthridone alkaloid, criasiaticidine A (1), was isolated from the bulbs of Crinum asiaticum var. japonicum, together with pratorimine (2), lycorine (3) and 4′-hydroxy-7-methoxyflavan (4). The structure of the new alkaloid was determined to be 4,5-etheno-9,10-dihydroxy-6-phenanthridone by spectroscopic means. The cytotoxicity of the isolated compounds 1-4 was evaluated in vitro against Meth-A (mouse sarcoma) and Lewis lung carcinoma (mouse lung carcinoma) tumor cell lines. Furthermore, 3 was examined for in vivo antitumor activity with LLC tumor cells.

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Min, B. S., Gao, J. J., Nakamura, N., Kim, Y. H., & Hattori, M. (2001). Cytotoxic alkaloids and a flavan from the bulbs of Crinum asiaticum var. japonicum. Chemical and Pharmaceutical Bulletin, 49(9), 1217–1219. https://doi.org/10.1248/cpb.49.1217

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