New triterpenoid saponins from fruit specimens of Panax japonicus collected in Toyama prefecture and Hokkaido (2)

Abstract

Four new dammarane-type triterpenoid saponins, chikusetsusaponin FT 1 (1), chikusetsusaponin FT2 (2), chikusetsusaponin FT3 (3), chikusetsusaponin FT4 (4), and six known triterpenoid saponins, chikusetsusaponin FK4 (8), chikusetsusaponin FK5 (9), chikusetsusaponin FK2 (10), chikusetsusaponin FK3 (11), chikusetsusaponin LN4 (12), and chikusetsusaponin IVa (14), were isolated from the fruits of Panax japonicus C. A. MEYER, collected in Toyama prefecture, Japan, and five new dammarane-type triterpenoid saponins, chikusetsusaponin FT1 (1), chikusetsusaponin FT3 (3), chikusetsusaponin FT4 (4), chikusetsusaponin FH1 (5), chikusetsusaponin FH2 (6), and eight known triterpenoid saponins, ginsenoside Re (7), chikusetsusaponin FK5 (9), chikusetsusaponin FK2 (10), chikusetsusaponin FK3 (11), chikusetsusaponin LN4 (12), 28-desglucosylchikusetsusaponin IVa (13), chikusetsusaponin IVa (14), and chikusetsusaponin V (15), were isolated from the fruits of P. japonicus C. A. MEYER, collected in Hokkaido, Japan. The structures of new chikusetsusaponins were elucidated on the basis of chemical and physicochemical evidences. © 2012 The Pharmaceutical Society of Japan.