We demonstrate the application of the 1,3-dipolar cycloaddition ("click" reaction) to couple gold nanoparticles (Au NPs) functionalized with low densities of functional ligands. The ligand coverage on the citrate-stabilized Au NPs was adjusted by the ligand:Au surface atom ratio, while maintaining the colloidal stability of the Au NPs in aqueous solution. A procedure was developed to determine the driving forces governing the selectivity and reactivity of citrate-stabilized and ligand-functionalized Au NPs on patterned self-assembled monolayers. We observed selective and remarkably stable chemical bonding of the Au NPs to the complimentarily functionalized substrate areas, even when estimating that only 1-2 chemical bonds are formed between the particles and the substrate. © 2013 by the authors; licensee MDPI, Basel, Switzerland.
Rianasari, I., de Jong, M. P., Huskens, J., & van der Wiel, W. G. (2013). Covalent coupling of nanoparticles with low-density functional ligands to surfaces via click chemistry. International Journal of Molecular Sciences, 14(2), 3705–3717. https://doi.org/10.3390/ijms14023705